Dose: 10 mg/kg/dose PO, IV
Allopurinol
| Dose: 10 mg/kg/dose PO, IV |
| Frequency: Q 8 hours |
| Comments: Allopurinol is a potent inhibitor of xanthine oxidase. This enzyme is responsible for the conversion of xanthine to uric acid. It is used to prevent hyperuricemia that may occur following treatment of neoplastic diseases in which rapid neoplastic tissue destruction occurs. Allopurinol has been reported to increase the half-life of theophylline. Allopurinol has also been shown to ameliorate hypoxic-ischemic neuronal and myocardial damage in adult animals by acting as a free radical scavenger and inhibiting xanthine oxidase. More comments on allopurinol. |
| Toxicity: Nausea, vomiting, and diarrhea are all common. To avoid GI upset, administer the drug following feedings. Allopurinol may also cause drowsiness and skin rashes. Adverse reactions associated with allopurinol. |
| Preparation: Allopurinol (Zyloprim) is available in a 20 mg/ml oral preparation made according to bulk compounding instructions on file at SJMMC. Refrigerate. Shake well prior to use. Stable for 8 weeks. The IV preparation is available under the FDA orphan drug program (Facts and Comparisons, Inc. Drug Facts and Comparisons. Olin, B.R. ed. St. Louis, MO:Facts and Comparisons, Inc; 1997, page 755). |
| Compatibility: No information available on filter, TPN, or other drugs. |
Weight (grams) |
Dose (ml) |
Weight (grams) |
Dose (ml) |
500 |
0.25 |
3000 |
1.50 |
1000 |
0.50 |
3500 |
1.75 |
1500 |
0.75 |
4000 |
2.00 |
2000 |
1.00 |
4500 |
2.25 |
2500 |
1.25 |
5000 |
2.50 |