dobutamine 1 mg/ml

DOBUTamine 1 mg/ml concentration beginning August 12 at SJMMC

DOBUTamine 2 mg/ml (old concentration)

Dobutamine may be associated with tissue injury if infiltrates. Use with caution in a peripheral or scalp IV.

Dose: 1 to 20 mcg/kg/min IV

Frequency: Continuous infusion (avoid infusing through UAC)

Comments: Dobutamine is a sympathomimetic amine used as a vasopressor to treat low output cardiac failure. Dobutamine does not depend upon the endogenous release of norepinephrine, as does dopamine, to increase cardiac output. However, clinically dobutamine has not appeared as effective as dopamine. Dobutamine appears to be more effective in cardiogenic shock. The onset of action can be seen in 2 minutes after the infusion is started, its peak effect is seen in 10 minutes, and it's half-life is 2 minutes. The combination of an infusion of both dobutamine and dopamine may allow the use of lower doses of both drugs. Further comments on dobutamine.

Toxicity: Dobutamine appears to be relatively safe when used with close monitoring of blood pressure and heart rate. It appears to be less prone to produce arrhythmias than either isoproterenol or dopamine. Side effects include tachycardia and changes in systolic blood pressure (either increasing or decreasing) which resolve upon lowering the infusion rates.

Preparation:
Caution: New Method of DOBUTamine Preparation!

Dobutamine (Dobutrex) is available in a 1 mg/ml standard concentration. Do not add to alkaline solutions, such as those containing sodium bicarbonate. The solution is stable for 7 days. Store at room temperature. Do not use if discolored. The infusion rate programed from the pump can be double checked using the link to:
drip check (450-1000 grams), The links for calculation checks are not ready
drip check (1000-2500 grams), The links for calculation checks are not ready
drip check (2500-5500 grams), The links for calculation checks are not ready
drip sheet calculator (must have microsoft excel installed).

Compatibility: Compatibility: Compatible with TPN, do not use filter. Also compatible withD₅W, D₁₀W, D₅ with sodium chloride, D₅LR, LR, NS, amrinone, atracurium, dopamine, enalaprilat, epinephrine, famotidine, hydralazine, isoproterenol, lidocaine, morphine, nitroprusside, pancuronium, procainamide, propranolol, ranitidine, streptokinase, tolazoline, vecuronium, and zidovudine. It is incompatible with acyclovir, alteplase, aminophylline, bumetanide, digoxin, doxapram, furosemide, phenytoin, phytonadione, potassium phosphate, and sodium bicarbonate, and any solution with a pH < 2.5 and > 5.5. It has equivocal compatibility with calcium chloride and gluconate, diazepam, heparin, insulin, magnesium sulfate, and potassium chloride..

Return to Home Page, A to C, D to H, I to M, N to Q, R to U, or V to Z.