Dose: 3 to 8 mcg/kg/dose IV, IM
           Oral dose: 40-100 mcg/kg/dose given every 6 to 8 hour (see preparation)

Comments: Glycopyrrolate is an anticholinergic drug that decreases tracheobronchial and pharyngeal secretions, decrease the volume and acidity of gastric secretions, and counteracts interoperative vagally mediated arrhythmias. It can also be used to block arrhythmias and excessive secretions due to neostigmine administration when it is used to reverse neuromuscular blockade. It does not easily cross the blood-brain barrier, like atropine and scopolamine, so it has less CNS side effects.  Glycopyrrolate contains benzyl alcohol, 0.9% as a preservative. More comments on glycopyrrolate.

Preparation: Glycopyrrolate (Robinol) is available in a 1 or 2 ml vials with a concentration of 0.2 mg/ml.. 
For parenteral use, it is further diluted to 0.02 mg/ml (20 mcg/ml) by using a 12 cc syringe. Draw 1 ml of the glycopyrrolate into the syringe. Remove needle. Replace with new needle. Then draw up 9 ml of normal saline or other compatible diluent. Draw in sufficient air to allow mixing of the 0.02 mg/ml solution. Infuse IVP.

For oral use, use the undiluted preparation 200 mcg/ml. Since this increases the dose by a factor of 10, this should prompt great care in writing for the medication as well as in its administration.

Compatibility: No information available on filter or TPN. It is compatible with D5W, D10W, D5NS, D10NS, NS, LR, atropine, fentanyl, lidocaine, midazolam, morphine, propofol, and ranitidine.  It is incompatible with chloramphenicol, dexamethasone, diazepam, and sodium bicarbonate. Do not mix with fluids with a pH greater than 6 such as a barbiturates.