Adverse effects associated with spironolactone

   Hyperkalemia may occur in patients with impaired renal function. Ordinarily, potassium supplementation should not be given to those receiving spironolactone. In addition, hyponatremia and hyperchloremic metabolic acidosis, and hypocalcemia can occur. It can also cause an increase in the BUN, especially in patients with pre-existing renal disease. Some gastrointestinal problems have been noted including cramping and diarrhea, gastritis, gastric ulceration, gastric bleeding, and vomiting. Lethargy, headache, mental confusion, erythematous cutaneous eruptions, and urticarial skin rashes have been reported. A few cases of agranulocytosis have also been reported. (Facts and Comparisons, Inc. Drug Facts and Comparisons. Olin, B.R. ed. St. Louis, MO:Facts and Comparisons, Inc; 1996, page 138h).

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