Dose:  1 mg/kg/dose PO

Frequency: Q 8 to 24 hours

Comments: Spironolactone and hydrochlorothiazide (Aldactazide) is a combination of diuretics.  The combination seeks to improve the efficacy of the two while decreasing the adverse effects. See hydrochlorothiazide and spironolactone. See diuretic for comparisons of the effects and complications of the different diuretics. . More information is available about the individual diuretics (spironolactone and hydrochlorothiazide) and comments on spironolactone with hydrochlorothiazide (Aldactazide).

Preparation: To prepare a 5 mg/ml concentration of Aldactazide use five (5) 25 mg tablets of Aldactazide. Remove tablet coating using a damp paper towel. Then, triturate the tablet in a mortar and pestle until a fine powder is obtained. Add 25 ml of simple syrup in small amounts, using it to evenly suspend and wash all of the drug out of the mortar into a 1 oz amber bottle. Label the bottle with drug, strength, date, time, initials, SHAKE WELL, REFRIGERATE, and STABILITY of 60 days.

To prepare a 1 mg/ml concentration of Aldactazide use ten (10) 25 mg tablets of Aldactazide. Add a small amount of water and soak for 5 minutes. Add 50 ml of 1.5% carboxymethylcellulose, 100 ml syrup NF, and mix. QSAD 250 ml with purified water. Stable at room temperature or refrigerate for three months (Nahafa. Ann Pharmacother 1993; 27:1198). Label the bottle with drug, strength, date, time, initials, SHAKE WELL and STABILITY of 90 days.